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Charles Kelley, PhD
Associate Professor of Chemistry

School of Arts and Sciences - F214


School of Arts & Sciences

Chemistry/Pharmaceutical Chemistry (BS/MS)

PhD, Organic Chemistry, Indiana University, 1970
BA, Chemistry, St. Josephs College, Rensselaer, IN., 1964

Areas of Teaching
Organic Chemistry
Spectroscopic Analysis
Synthetic Preparations

Scholarly Interests

Organic Synthesis of (a) Stable fluorescent benzothiazoles and benzoxazoles of the ESIPT type , (b) Selective inhibitors of dopamine reuptake and D-3 receptors, (c) fluorescent compounds of the oligophenylene type. Isolation and structural identification of novel compounds from plants.

Mark Froimowitz, Yonghong Gu, Les A. Dakin, Pamela M. Nagafuji, Charles J. Kelley, Damon Parrish, Jeffrey R. Deschamps, and Aaron Janowsky, Slow-Onset, Long-Duration, Alkyl Analogues of Methylphenidate with Enhanced Selectivity for the Dopamine Transporter Journal of Medicinal Chemistry (2007), 50(2), 219 - 232.

Froimowitz, Mark; Gu, Yonghong; Dakin, Les A.; Kelley, Charles J.; Parrish, Damon; Deschamps, Jeffrey R. Vinylogous amide analogs of methylphenidate. Bioorganic & Medicinal Chemistry Letters (2005), 15(12), 3044-3047.

Bischoff, Theodore A.; Kelley, Charles J.; Karchesy, Yvette; Laurantos, Maria; Nguyen-Dinh, Phuc; Arefi, Abdul Ghafoor. Antimalarial activity of Lactucin and Lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L. Journal of Ethnopharmacology (2004), 95(2-3), 455-457.

Greenblatt, David J.; von Moltke, Lisa L.; Harmatz, Jerold S.; Chen, Gengsheng; Weemhoff, James L.; Jen, Cheng; Kelley, Charles J.; LeDuc, Barbara W.; Zinny, Miguel A. Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice. Clinical Pharmacology & Therapeutics (2003), 74(2), 121-129.

DeMott, James M., Jr.; Kelley, Charles J. In the laboratory: the microscale laboratory: an alternative one-step procedure for the conversion of piperonal to piperonylonitrile. Journal of Chemical Education (2001), 78(6), 780.

Kelley, Charles J.; Ansu, Kwabena; Budisusetyo, Wiranto; Ghiorghis, Alem; Qin, Yuanxi; Kauffman, Joel M. Syntheses and photophysical properties of some 4-arylpyridinium salts. Journal of Heterocyclic Chemistry (2001), 38(1), 11-23.

Kelley, Charles J.; Ghiorghis, Alem; Qin, Yuanxi; Kauffman, Joel M.; Novinski, John A.; Boyko, Walter J. Synthesis of Bridged Oligophenylenes from Fluorene. Part 2.1 Quinquiphenyls to Deciphenyls. Journal of Chemical Research, Synopses (1999), (2), 80-81, Manuscript, 401-418.

Foye, William O.; Dabade, Sunil V.; Kelley, Charles J.; Lebrun, Evelyne; Van Rapenbusch, Roland. Synthesis and dihydrofolate reductase inhibitory activity of N4-2-L-glutaryl-N1-heteroaryl thiosemicarbazones. Medicinal Chemistry Research (1998), 8(9), 542-553.

Kelley, Charles J.; Ghiorghis, Alem; Kauffman, Joel M. Synthesis of bridged oligophenylenes from fluorene. Part 1. Ter- and quater-phenyls. Journal of Chemical Research, Synopses (1997), (12), 446-447, Manuscript 2701-2733.

Kauffman, Joel M.; Litak, Peter T.; Novinski, John A.; Kelley, Charles J.; Ghiorghis, Alem; Qin, Yuanxi. Electronic absorption and emission spectral data and fluorescence quantum yields of bridged p-oligophenylenes, bi- to deciphenyls, and related furans and carbazoles. Journal of Fluorescence (1995), 5(3), 295-305.

Current Professional Memberships, Service & Leadership

American Chemical Society

Personal Interests
Amateur botany
Rhode Island Tree Association
Alternative Energy Sources
Public transportation