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Bio

Stephen Kerr, PhD
Professor of Medicinal Chemistry
Vice-Chair Department of Pharmaceutical Sciences

Department/Office
School of Pharmacy - W319

Contact
stephen.kerr@mcphs.edu
(P)617.732.2093
(F)617.732.2228

Schools
School of Pharmacy - Boston

Programs
Chemistry/Pharmaceutical Chemistry (BS/MS)
Pharmacy (PharmD)
Pharmaceutical Sciences (BS)
Pharmacology & Toxicology (BS)

Education
PhD in Medicinal Chemistry, University at Buffalo (SUNY)
BS (Pharmaceutical Technology), Department of Chemical Technology, Bombay University
BS (Chemistry), St. Xavier's College, Bombay University
Post-doctoral Fellow, Yale University School of Medicine


Affiliated Appointments
Faculty Mentor, Academic Resource Center
Faculty Advisor, Graduate Student Association
Faculty Advisor, Indian Student Association


Areas of Teaching
Medicinal Chemistry
Biotechnology
Organic Chemistry
Bio-organic Chemistry
Biochemistry


Scholarly Interests
Mechanistic enzymology of viral DNA polymerases
Anti-viral and anti-cancer drug and pro-drug design
Cellular toxicology of phenolic anti-oxidants in cell culture models
Drug metabolism studies


Honors
2014 Faculty Scholarship Showcase Award (Integration)
2014 Phi Kappa Phi – Charter Member
2012 Distinguished Trustees Award for Teaching Excellence
2011 Pharmaceutical Sciences Teacher of the Year Award
2010 Scholarly Publication Award (Basic Sciences) - MCPHS
2010 One Year Faculty Service Award, MCPHS
2007 Long Term Faculty Service Award, MCPHS
2007 Phi Lambda Sigma (National Pharmacy Leadership Society) - Faculty Inductee
2004 Short Term Faculty Service Award, MCPHS
2003 Rho Chi (Academic Honor Society in Pharmacy) - Faculty Inductee
2002 Sigma Xi (Scientific Research Society) - Inductee
1999 Scholarly Publication Award (Basic Sciences) - MCPHS
1992 -1996 Post-doctoral Research Fellowship, Yale University School of Medicine

Publications
Silva MA, Chuong M, Kerr S, Cabrera A. (2013) “Stability of two long acting insulin formulations after 28 days” J Pharmacy Practice and Research, 43, 37-40.

Kerr, S.G. (2012) “Drug Discovery Through Enzyme Inhibition” In Foye’s Principles of Medicinal Chemistry. Eds. T. Lemke and D.W. Williams. (7th. ed . Lippincott, Williams and Wilkins, Baltimore, USA)

Chen M, Howe, D, LeDuc, B, Kerr, SG and Williams, DA. (2010) "Identification of Human UGT2B7 as the Major Isoform Involved in the O-Glucuronidation of Chloramphenicol." Drug Metab. Dispos. 38: 368 - 375.

R. Sarangarajan, G. Acquaah-Mensah, K. A. Hoey, S. Kerr (2009). Transition From Primary To Metastatic Melanoma Is Associated With Differential Expression Of Genes Regulating Intracellular Levels Of Glutathione (GSH). Melanoma and Pigment Cell Research, 22 (7),PP10-3, 317, 2009.

G. Acquaah-Mensah, K. A. Hoey, S. Kerr and R. Sarangarajan.(2009) "Transcriptional regulatory relationships involving Glutathione S-Transferase (GST) and oxidative stress related gene products: targets influencing melanotoxicity of substituted phenols." The Toxicologist CD - An official Journal of the Society of Toxicology, Volume 102, Number S-1, PS 935, March 2009.

K. A. Hoey, S. Kerr and R. Sarangarajan (2009). "Expression/activity of Glutathione S-Transferase isoform (GST-?) is associated with increased sensitivity to 4-tertiary butylphenol (4-TBP) toxicity: implications for occupational vitiligo." The Toxicologist CD - An official Journal of the Society of Toxicology, Volume 102, Number S-1, PS 1054, March 2009.

Sarangarajan, R., Friel, C and Kerr, S (2008) . "Characterization of the interaction between antioxidants and 4-TBP in the etiology of occupational vitiligo." Melanoma and Pigment Cell Research, 21 (7),PP10-3, 317, 2008.

Kerr, S.G. (2007) "Drug Discovery Through Enzyme Inhibition" in Foye's Principles of Medicinal Chemistry. Eds. T. Lemke and D.W. Williams. (6th. ed . Lippincott, Williams and Wilkins, Baltimore, USA)

Chen M, Howe, D, LeDuc, B, Kerr, SG and Williams, DA. (2007). "Identification and Characterization of Two Chloramphenicol Glucuronides from the in vitro Glucuronidation of Chloramphenicol in Human Liver Microsomes." Xenobiotica 37 (9): 954 -971.

Kerr SG and Anderson KS. (1997) "Pre-Steady State Kinetic Characterization of Wild Type and 3'-Azido-3'-deoxythymidine (AZT) Resistant Immunodeficiency Virus Type 1 Reverse Transcriptase: Implication of RNA Directed DNA Polymerization in the Mechanism of AZT Resistance." Biochemistry 36, 14064 - 14070.

Kerr SG and Anderson, KS. (1997) “RNA Dependent DNA Replication Fidelity of HIV-1 Reverse Transcriptase: Evidence of Discrimination Between DNA and RNA Substrates.” Biochemistry 36, 14056 – 14063.

Kerr, S. G. and Kalman, T.I. (1994) “N4-(Dialkylamino)methylene Derivatives of 2’-deoxycytidine and Arabinosyl Cytosine: Physicochemical Studies for Potential Prodrug Applications.” J. Pharm. Sci. 83: 582 586.

Kerr, S. G. and Kalman, T.I. (1992) "Highly Water Soluble Lipophilic Prodrugs of the Anti-HIV Nucleoside Analogue 2',3'-Dideoxycytidine (ddC) and it's 3'-Fluoro Derivative." J. Med. Chem. 35: 1996 - 2001.


Current Professional Memberships, Service & Leadership
American Society for Pharmacology and Experimental Therapeutics (ASPET)
American Association of Colleges of Pharmacy
Sigma Xi - Scientific Research Society - Vice President (Delta Chapter)
American Association for the Advancement of Science
Society of Toxicology (SOT)
American Association of Pharmaceutical Scientists (AAPS)
Rho Chi (Pharmacy Honor Society)
Phi Lambda Sigma (Pharmacy Leadership Society)
Phi Kappa Phi (Honor Society)


Personal Interests
Reading
Traveling
Music