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Stephen Kerr, PhD
Associate Professor of Medicinal Chemistry
Vice-Chair Department of Pharmaceutical Sciences

Department/Office
School of Pharmacy - W324

Contact
stephen.kerr@mcphs.edu
(P)617.732.2093
(F)617.732.2228

Schools
School of Pharmacy - Boston

Programs
Chemistry/Pharmaceutical Chemistry (BS/MS)
Pharmacy (PharmD)
Pharmaceutical Sciences (BS)
Pharmacology & Toxicology (BS)

Education
PhD in Medicinal Chemistry, University at Buffalo (SUNY)
BS (Pharmaceutical Technology), Department of Chemical Technology, Bombay University
BS (Chemistry), St. Xavier's College, Bombay University
Post-doctoral Fellow, Yale University School of Medicine


Affiliated Appointments
Chair, Graduate Studies Curriculum Committee
Faculty Advisor, Academic Resource Center
Faculty Advisor, Graduate Student Association
Faculty Advisor, Indian Student Association


Areas of Teaching
Medicinal Chemistry
Biotechnology
Organic Chemistry
Bio-organic Chemistry
Biochemistry


Scholarly Interests
Mechanistic enzymology of viral DNA polymerases.
Anti-viral and anti-cancer drug and pro-drug design
Cellular toxicology of phenolic anti-oxidants in cell culture models
Drug metabolism studies


Honors
Honors
2010-2011 Pharmaceutical Sciences Teacher of the Year Award
Scholarly Publication Award (Basic Sciences) - MCPHS -2010
One Year Faculty Service Award, MCPHS - 2010
Long Term Faculty Service Award, MCPHS - 2007
Phi Lambda Sigma (National Pharmacy Leadership Society) - Faculty Inductee, 2007
Short Term Faculty Service Award, MCPHS - 2004
Rho Chi (Academic Honor Society in Pharmacy) - Faculty Inductee, 2003
Sigma Xi (Scientific Research Society) Inductee, 2002
Scholarly Publication Award (Basic Sciences) - MCPHS -1999
Post-doctoral Research Fellowship, Yale University School of Medicine (1992- 96) 


Publications
Chen M, Howe, D, LeDuc, B, Kerr, SG and Williams, DA. (2010) "Identification of Human UGT2B7 as the Major Isoform Involved in the O-Glucuronidation of Chloramphenicol." Drug Metab. Dispos. 38: 368 - 375.

R. Sarangarajan, G. Acquaah-Mensah, K. A. Hoey, S. Kerr (2009). Transition From Primary To Metastatic Melanoma Is Associated With Differential Expression Of Genes Regulating Intracellular Levels Of Glutathione (GSH). Melanoma and Pigment Cell Research, 22 (7),PP10-3, 317, 2009.

G. Acquaah-Mensah, K. A. Hoey, S. Kerr and R. Sarangarajan.(2009) "Transcriptional regulatory relationships involving Glutathione S-Transferase (GST) and oxidative stress related gene products: targets influencing melanotoxicity of substituted phenols." The Toxicologist CD - An official Journal of the Society of Toxicology, Volume 102, Number S-1, PS 935, March 2009.

K. A. Hoey, S. Kerr and R. Sarangarajan (2009). "Expression/activity of Glutathione S-Transferase isoform (GST-?) is associated with increased sensitivity to 4-tertiary butylphenol (4-TBP) toxicity: implications for occupational vitiligo." The Toxicologist CD - An official Journal of the Society of Toxicology, Volume 102, Number S-1, PS 1054, March 2009.

Sarangarajan, R., Friel, C and Kerr, S (2008) . "Characterization of the interaction between antioxidants and 4-TBP in the etiology of occupational vitiligo." Melanoma and Pigment Cell Research, 21 (7),PP10-3, 317, 2008.

Kerr, S.G. "Drug Discovery Through Enzyme Inhibition" in Foye's Principles of Medicinal Chemistry. Eds. T. Lemke and D.W. Williams. (6th. ed . Lippincott, Williams and Wilkins, Baltimore, USA) October 2007. Kerr, S. G. and Anderson, K. S. (1997)

Biochemistry 36, 14064 - 14070. "Pre-Steady State Kinetic Characterization of Wild Type and 3'-Azido-3'-deoxythymidine (AZT) Resistant Immunodeficiency Virus Type 1 Reverse Transcriptase: Implication of RNA Directed DNA Polymerization in the Mechanism of AZT Resistance."

Kerr, S. G. and Kalman, T.I. (1992) J. Med. Chem. 35: 1996 - 2001. "Highly Water Soluble Lipophilic Prodrugs of the Anti-HIV Nucleoside Analogue 2',3'-Dideoxycytidine (ddC) and it's 3'-Fluoro Derivative."


Current Professional Memberships, Service & Leadership
American Association of Colleges of Pharmacy
Sigma Xi - Scientific Research Society - Vice President (Delta Chapter)
American Association for the Advancement of Science
Society of Toxicology (SOT)
American Association of Pharmaceutical Scientists (AAPS)
Rho Chi (Pharmacy Honor Society)
Phi Lambda Sigma (Pharmacy Leadership Society)


Personal Interests
Reading
Traveling
Music