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Ahmed Mehanna, PhD
Professor of Medicinal Chemistry

Department/Office
School of Pharmacy - W326

Contact
ahmed.mehanna@mcphs.edu
(P)617.732.2955


Schools
School of Pharmacy - Boston

Programs
Chemistry/Pharmaceutical Chemistry (BS/MS)
Pharmaceutical Sciences (BS)
Pharmaceutics (MS)
Pharmacology & Toxicology (BS)
Medicinal Chemistry (MS)

Education
PhD in Medicinal Chemistry, 1986
School of Pharmacy
University of Pittsburgh, Pittsburgh, Penn. 


Areas of Teaching
Undergraduate: Medicinal Chemistry
Graduate: Heterocyclic Chemistry
Chemistry of Peptides and Proteins
Advanced Medicinal Chemistry


Scholarly Interests
Educational Articles

Drug Design:
Design, Synthesis and Biological Testing of hemoglobin-S antigelling agents, for potential use as drugs to treat Sickle Cell Anemia.

Design, Synthesis and Biological Testing of Novel Calcium Channel blockers for potential use as antihypertensive, antianginal, and antiarrhythmic agents.

Design, Synthesis and Biological Testing of non-competitive inhibitors for Angiotensin Converting Enzyme for potential use as antihypertensive, antianginal and antiarrhythmic agents.

Design, Synthesis and Biological Testing of Hemoglobin Modifiers, for potential use as anticancer agents.

Development of Analytical Techniques to evaluate the biological activities of Organic compounds, especially in the areas of ACE inhibitors and Sickle Cell Research. 


Editorials
Ahmed S. Mehanna, Book review, J. Med. Chem., 2003, Vol. 46, No.14, page 3178.

Reviewer for a manuscript titled: Metabolic Considerations in Prodrug Design, by: Luc P.Balant, for publication in Burgers Medicinal Chemistry and Drug Discovery, 6th edition, 2003, John Wiley and Sons, Inc.

Reviewer for the Journal of Medicinal Chemistry for a book titled: Cardiovascular Pharmacotherapeutics, second edition , 2003, by William H. Frishman, Edmund H. Sonnenblick and Dominic A. Sica (Eds), Second Edition, McGraw -Hill Medical Publishing Divis

Reviewer for a manuscript on non-nucleoside reverse transcriptase inhibitors, Reviewed for the journal: ACurrent Pharmaceutical Design,January 2002.

Wilson & Gisvolds Textbook of Organic Medicinal Pharmaceutical Chemistry Reviewed for Lippincott Williams & Wilkins, Baltimore, MD., Tenth Edition, July, 2001. 


Honors
School of Pharmacy-Pharmaceutical Sciences - Teacher of the Year, May 2008
School of Pharmacy teacher of the year Award, May 2004
School of Pharmacy teacher of the year Award, May 2002
Advisor of the year Award, Massachusetts College of Pharmacy and Allied Health Sciences June 1998
Advisor of the year Award, Massachusetts College of Pharmacy and Allied Health Sciences June 1995
Advisor of the year Award, Massachusetts College of Pharmacy and Allied Health Sciences June 1993

Excellence in Scholarly Publication Award, Massachusetts College of Pharmacy and Allied Health Sciences, 1991 

Nase Z. Alsharif, Kimberly A. Galt, Ahmed S. Mehanna, Robert Chapman, and Alaba M. Ogunbadeniyi. Instructional Model to Teach Clinically Relevant Medicinal Chemistry. American Journal of Pharmaceutical Education, 2006; 70(4), Article 91, page1-12.

Trusteees Award for Teaching Excellence: Massachusetts College of Pharmacy and Allied Health Sciences, May1997Ahmed S. 

Mehanna. Insulin and Oral Anti-diabetic Agents American Journal of Pharmaceutical Education, 2005; 69(5), 1-11.

Ahmed S. Mehanna, NSAIDs: Chemistry and Pharmacological Actions, American Journal of Pharmaceutical Education. 2003; 67 (2), 1-7.

Ahmed S. Mehanna and Jinyung Kim, Design, synthesis, and biological testing of thiosalicylamide derivatives as a novel class of Calcium Channel Blockers. Bioorganic & Medicinal Chemistry. 13, 4323-4331, 2005.

Mehanna, A.S. Sickle Cell Anemia and Antisickling Agents Then and Noww Current Medicinal Chemistry, 8, 79-88, 2001.

Mehanna, A.S. and Dowling, M. Liquid Chromatographic Determination of Hippuric acid for The Evaluation of Ethacrynic Acid as Angiotensin Converting Enzyme Inhibitor. Journal of Pharmaceutical and Biomedical Analysis, 19, 967-973 (1999).

Ahmed S.Mehanna. Medicinal Chemistry Case studies in: Mastering Pharmacy Licensure &Certification, part II, By Kosgarten, and Pisano (editors), McGraw-Hill, Inc. 2006.

Ahmed S. Mehanna, Rationale of Design of Anti-HIV drugs. Burgerrs Medicinal Chemistry and Drug Discovery, 6th Edit. Volume V, Chapter 11, pp 457-483. Abraham, D.J. (editor), John Wiley and Sons Inc., New York, NY, 2003.

Cardiac Agents, Foyees Principles of Medicinal Chemistry, chapter 21, Williams, D. Lemke, T. (editors). Lippincott Williams and Wilkns, 2002.

PATENTS:
1. Mehanna, A.S. and Kim, J.T. Calcium Channel Blockers US patent # 6,951,860 B2, October 4, 2005.
2. Mehanna, A.S. and Kim, J.T. Calcium Channel Blockers. United States Patent # 6541479 B1, March 2003.
3. Abraham,D.J.; Mahran,


Current Professional Memberships, Service & Leadership
AACP, 1997-present
ACS, 1990-present


Personal Interests
Reading
Sports: soccer, boxing