George Acquaah-Mensah, PhD, RPh
Professor of Pharmaceutical Sciences
School of Pharmacy
- DBEN 515
School of Pharmacy - Worcester/Manchester
Pharmacy (Accelerated PharmD)
BPharm, University of Science and Technology, Ghana
PhD, University of Texas at Austin
Post-Doctoral Fellowship, University of Colorado School of Medicine
Molecular insights into disease etiology and addiction
Functional Bioinformatics including the use of machine learning and automated reasoning to elucidate regulation of gene expression in disease, drug action, drug toxicity and personalized medicine
Peer-Reviewed Articles & Book Chapters
Acquaah-Mensah GK, and Taylor RC. Brain in situ Hybridization Maps as a Source for Reverse-Engineering Transcriptional Regulatory Networks: Alzheimer Insights. Gene 586:77–86 doi: 10.1016/j.gene.2016.03.045 (2016)
Acquaah-Mensah, GK, Agu, N, Khan, T, Gardner, A. A Regulatory Role for the Insulin- and BDNF-Linked RORa in the Hippocampus: Implications for Alzheimer Disease. Journal of Alzheimer's Disease 44: 827–838 doi: 10.3233/JAD-141731 (2015).
Adabor, ES, Acquaah-Mensah, GK, Oduro, FT. SAGA: A Hybrid Search Algorithm for Bayesian Network Structure Learning. Journal of Biomedical Informatics. 53: 27–35. doi: 10.1016/j.jbi.2014.08.010 (2015).
Weathers, PJ, Elfawal, MA, Towler, MJ, Acquaah-Mensah, GK, Rich, SM. Pharmacokinetics of artemisinin delivered by oral consumption of Artemisia annua dried leaves in healthy vs. Plasmodium chabaudi-infected mice. Journal of Ethnopharmacology. 153: 732–736 (2014).
Adabor, ES, Acquaah-Mensah, GK, Oduro, FT. Inferring Transcriptional Regulatory Relationships among Genes in Breast Cancer: An Application of Bayes' Theorem. International Journal of Statistics and Probability 3 (2): 52 -62 (2014).
Singh A, Happel C, Manna S, Acquaah-Mensah, GK, Carretero J, Kumar S, Nasipuri P, Kraubsz K, Wakabayashi N, Dewi R, Boros L, Gonzalez F, Gabrielson E, Wong K-K, Girnun G, Biswal S. Nrf2 regulates miR-1 and miR-206 to drive Tumorigenesis. Journal of Clinical Investigation. 123(7):2921–2934. doi:10.1172/JCI66353 (2013).
Acquaah-Mensah, GK, Taylor, RC, and Bhave, SV. PACAP Interactions in the Mouse Brain: Implications for Behavioral and Other Disorders. Gene 491: 224–231. 10.1016/j.gene.2011.09.017 (2012).
Sheng JJ, and Acquaah-Mensah GK. Subcellular location and molecular mobility of human cytosolic sulfotransferase 1C1 in living human embryonic kidney 293 cells. Drug Metabolism and Disposition 39(8):1334-1337 (2011).
Taylor, RC, Acquaah-Mensah, G, Singhal, M, Malhotra, D, and Biswal, S. Network Inference Algorithms Elucidate Nrf2 Regulation of Mouse Lung Oxidative Stress. PLoS Computational Biology 4(8): e1000166 doi:10.1371/journal.pcbi.1000166 (2008).
Baumgartner WA Jr, Cohen KB, Fox LM, Acquaah-Mensah G, and Hunter L. Manual curation is not sufficient for annotation of genomic databases. Bioinformatics 23(13):i41-8 (2007). [Selected and reprinted in the International Medical Informatics Association’s Yearbook of Medical Informatics 2008.]
Current Professional Memberships, Service & Leadership
Research Society on Alcoholism
International Society for Computational Biology
Society of Toxicology