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Bio

Carolyn Friel, PhD, RPh
Chair, Department of Pharmaceutical Sciences
Professor of Medicinal Chemistry

Department/Office
School of Pharmacy - 520

Contact
carolyn.friel@mcphs.edu
(P)508.373.5612


Schools
School of Pharmacy - Worcester/Manchester

Programs
Pharmacy (Accelerated PharmD)

Education
BSP, University of Rhode Island
PhD, Medicinal Chemistry, Northeastern University


Areas of Teaching

Medicinal Chemistry



Scholarly Interests
Drug design and organic synthesis
Molecular modeling
Analytical chemistry


Honors
Teacher of the Year, Department of Pharmaceutical Sciences 2006-2007
APhA Teacher Appreciation Award Massachusetts College of Pharmacy 2002-2003 Class of 2004; 2006-2007 Class of 2008
SGA P2 Professor of the Year Class of 2010
SGA P2 Professor of the Year Class of 2010, Class of 2011

Hanson RN, Friel CJ, Dilis R, Hughes A, and DeSombre ER. (2005) Synthesis and Evaluation of (17 a,20Z)-21-(4-Substituted-phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17 ß-diols as Ligands for the Estrogen Receptor-aHormone Binding Domain: Comparison with 20E-Isomers. J. Med. Chem; 48(13); 4300-4311.

Mobley JA, L'Esperance JO, Wu M, Friel CJ, Hanson RN, and Ho SM. (2004) The novel estrogen 17 a-20Z-21-[(4-amino) phenyl]-19-norpregna-1,3,5(10),20-tetraene-3,17 ß-diol induces apoptosis in prostate cancer cell lines at nanomolar concentrations in vitro. Mol. Cancer Ther. 3: 587-596.

Hanson RN, Lee CY, Friel CJ, Hughes A, and DeSombre ER. (2003) Evaluation of 17alpha-E-(trifluoromethylphenyl) vinyl estradiols as novel estrogen receptor ligands. Steroids 68:143-8.

Hanson RN, Lee CY, Friel CJ, Dilis R, Hughes A, DeSombre ER. (2003) Synthesis and evaluation of 17 a20E-21-(4-substituted phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17 ß-diols as probes for the estrogen receptor hormone binding domain. Journal of Medicinal Chemistry 46(14):2865-2876.

Sebag A, Friel CJ, Hanson RN, Forsyth D. (2000) Conformational Studies on (17 a,20Z)-21-(x-phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17 ß-diols Using 1D and 2D NMR spectroscopy and GIAO Calculations of 13C Shieldings. Journal of Organic Chemistry 65(23): 7902-7912.

Friel CJ. Ch. 22 Anesthetics In: Beale JM, Jr, Block JH, editors. Wilson and Gisvolds Textbook of Organic Medicinal and Pharmaceutical Chemistry. 12th ed. Philadelphia, PA: Wolters Kluwer Lippincott Williams and Wilkins; 2011; p. 711-32.

Friel CJ and Lu, M.. Ch. 24 Analgesic Agents In: Beale JM, Jr, Block JH, editors. Wilson and Gisvolds Textbook of Organic Medicinal and Pharmaceutical Chemistry. 12th ed. Philadelphia, PA: Wolters Kluwer Lippincott Williams and Wilkins; 2011; p. 776-818.

Friel CJ, Eliadi C, Pesaturo KA (2010) Local Anesthetic Use in Perioperative Areas, Perioperative Nursing Clinics 5(2), 203-214.


Current Professional Memberships, Service & Leadership
American Association of Colleges of Pharmacy
AACP Section of Teachers of Chemistry -
Programming Committee and Mentoring Committee
NABP/FPGEE Committee Member
Rho Chi National Honor Society
Academic Standing Committee
Faculty Counci