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Gerard D'Souza, Ph.D
Associate Professor of Pharmaceutics
Assistant Director of Assessment

Department/Office
School of Pharmacy - W318

Contact
Gerard.D'Souza@mcphs.edu
(P)617.735.1091


Schools
School of Pharmacy - Boston

Programs
Pharmacy (PharmD)
Pharmaceutical and Healthcare Business (BS)
Pharmaceutical Sciences (BS)
Pharmaceutics (MS)
Pharmacology & Toxicology (BS)

Academic and Administrative Appointments
Graduate Studies


Education
PhD, Northeastern University
MS, Northeastern University
BPharm, Goa College of Pharmacy, Panaji, Goa, India


Areas of Teaching
Pharmaceutics
Physical Pharmacy
Pharmaceutical Technology
Novel Drug Delivery Systems


Scholarly Interests
Pharmaceutical Nanocarriers
Subcellular Targeting
Gene Therapy
Mitochondrial DNA Diseases


Honors
2003 John L Neumeyer Research Fellowship

Torchilin VP, Levchenko TS, Rammohan R, Volodina N, Papahadjopoulos-Sternberg B, D'Souza GG. (2003). Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome-DNA Complexes. Proc Natl Acad Sci U S A. Feb 18;100(4):1972-7.

SV Boddapati, P Tongcharoensirikul, RN Hanson, GGM D'Souza, VP Torchilin, V Weissig. (2005). Mitochondriotropic liposomes. J Liposome Res. 15: 49-58.

GGM D'Souza, SV Boddapati, V Weissig. (2005). Mitochondrial leader sequence-plasmid DNA conjugates delivered into mammalian cells by DQAsomes co-localize with mitochondria. Mitochondrion Oct; 5(5):352-8.

E Katrangi, GGM D'Souza, BW Bigger, M Kulaweizk, K Singh, V Weissig. (2007) Xenogenic transfer of isolated murine mitochondria into human ?0 cells can improve respiratory function. Rejuvenation Research Dec;10(4):561-70.

GGM D'Souza, S Cheng, SV Boddapati, RW Horobin, V Weissig (2008) Nanocarrier-assisted sub-cellular targeting to the site of mitochondria improves the pro-apoptotic activity of paclitaxel. J Drug Targeting Aug;16(7):578-85.

GGM D'Souza, T Wang, K Rockwell, VP Torchilin (2008) Surface modification of pharmaceutical nanocarriers with ascorbate residues improves their tumor cell association and killing and the cytotoxic action of encapsulated paclitaxel in vitro. Pharmaceutical Research Jul 11. [Epub ahead of print]

SV Boddapati, GGM D'Souza, S Erdogan, VP Torchilin, V Weissig (2008) Organelle-targeted nanocarriers: Specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo. Nanoletters Jul 9. [Epub ahead of print]

GGM D'Souza and V Weissig (2004). Approaches to mitochondrial gene therapy. Current Gene Therapy. Sep:4(3):317-328.

SV Boddapati, S Cheng, GGM D'Souza and V Weissig (2006) Mitochondriotropic Particulate Drug and DNA Delivery Systems, in Handbook of Particulate Drug Delivery. American Scientific Publishers. MNV Ravi Kumar, Ed.

V Weissig, SV Boddapati, GGM. D'Souza, RW Horobin (2007) Functionalization of Pharmaceutical Nanocarriers for Mitochondria-targeted Drug and DNA Delivery, in Multifunctional Pharmaceutical Nanocarriers Vladimir P. Torchilin (Ed.). In Print.


Personal Interests
Bicycling and vintage bicycles
Photography and vintage cameras
Gardening