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Paul Kaplita, PhD
Associate Professor of Pharmaceutical Sciences

School of Pharmacy - DBEN 518


School of Pharmacy - Worcester/Manchester

Pharmacy (Accelerated PharmD)
Pharmacology (MS)

Postdoctoral Fellow, Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH
PhD, Biochemical Pharmacology, University at Buffalo, State University of New York
BS, Biological Sciences, University of Connecticut, Storrs

Professional Licensure/Certification
Principles of Pharmacokinetics and Toxicokinetics for the Industrial Scientist, University of Arizona College of Pharmacy, Tucson, AZ, 2008
Pharmacokinetics for Pharmaceutical Scientists, University of California San Francisco School of Pharmacy, San Francisco, CA, 2009

Areas of Teaching

Scholarly Interests
ADME profiling
High throughput screening
Laboratory automation
Systems pharmacology

P.Kaplita, H.Hu, L.Liu, T.Farrell, H.Grbic and D.Spero, Automatable formats of higher throughput ADMET profiling for drug discovery support, Journal of the Association for Laboratory Automation 10:140-148 (2005)

T.Morwick, A.Berry, J.Brickwood, M.Cardozo, K.Catron, M.DeTuri, J.Emeigh, C.Homon, M.Hrapchak, S.Jacober, S.Jakes, P.Kaplita, T.Kelly, J.Ksiazek, M.Liuzzi, R.Magolda, C.Mao, D.Marshall, D.McNeil, A.Prokopowicz, C.Sarko, E.Scouten, C.Sledziona, S.Sun, J.Watrous, J.P.Wu and C.Cywin, Evolution of the thienopyridine class of inhibitors of IKK-beta: Part I-Hit to lead strategies, Journal of Medicinal Chemistry 49:2898-2908 (2006)

C.L.Cywin, G.Dahmann, A.S.Prokopowicz, E.R.Young, R.L.Magolda, M.G.Cardozo, D.A.Cogan, D.DiSalvo, J.D.Ginn, M.A.Kashem, J.P.Wolak, C.A.Homon, T.M.Farrell, H.Grbic, H.Hu, P.V.Kaplita, L.H.Liu, D.M.Spero, D.D.Jeanfavre, K.M.OShea, D.M.White, J.R.Woska and M.L.Brown, Discovery of potent and selective PKC-theta inhibitors, Bio-organic and Medicinal Chemistry Letters 17:225-230 (2007)

H.Takahashi, Y.Bekkali, A.J.Capolino, T.Gilmore, S.E.Goldrick, P.V.Kaplita, L.Liu, R.M.Nelson, D.Terenzio, J.Wang, L.Zuvela-Jelaska, J.Proudfoot, G.Nabozny and D.Thomson, Discovery and SAR study of novel dihydroquinoline-containing glucocorticoid receptor agonists, Bio-organic and Medicinal Chemistry Letters 17:5091-5095 (2007)

R.J.Tatake, M.M.ONeill, C.A.Kennedy, A.L.Wayne, S.Jakes, D.Wu, S.Z.Kugler, M.A.Kashem, P.Kaplita and R.J.Snow, Identification of pharmacological inhibitors of the MEK5/ERK5 pathway, Biochemical and Biophysical Research Communications 377:120-125 (2008)

M.P.Winters, D.J.Robinson, H.H.Khine, S.S.Pullen, J.R.Woska, E.L.Raymond, R.Sellati, C.L.Cywin, R.J.Snow, M.A.Kashem, J.P.Wolak, J.King, P.V.Kaplita, L.H.Liu, T.M.Farrell, R.DesJarlais, G.P.Roth, H.Takahashi and K.J.Moriarty, 5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk), Bio-organic and Medicinal Chemistry Letters 18:5541-5544 (2008)

K.J.Moriarty, M.Winters, L.Qiao, D.Ryan, R.DesJarlais, D.Robinson, B.N.Cook, M.A.Kashem, P.V.Kaplita, L.H.Liu, T.M.Farrell, H.H.Khine, J.King, S.S.Pullen, G.P.Roth, R.Magolda and H.Takahashi, Itk kinase inhibitors: Initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead, Bio-organic Chemistry and Medicinal Chemistry Letters 18:5537-5540 (2008)

T.Morwick, F.H.Buettner, C.L.Cywin, G.Dahmann, E.Hickey, S.Jakes, P.Kaplita, M.A.Kashem, S.Kerr, S.Kugler, W.Mao, D.Marshall, Z.Paw, C.K.Shih, F.Wu and E.Young, Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of rho kinase, Journal of Medicinal Chemistry 53:759-777 (2010)

F.Wu, F.H.Buettner, R.Chen, E.Hickey, S.Jakes, P.Kaplita, M.A.Kashem, S.Kerr, S.Kugler, Z.Paw, A.Prokopowicz, C.K.Shih, R.Snow, E.Young and C.L.Cywin, Substituted 2H-isoquinolin-1-one as potent rho-kinase inhibitors: Part 1: Hit-to-lead account, Bio-organic and Medicinal Chemistry Letters 20:3235-3239 (2010)

Personal Interests
Nordic and Alpine Skiing