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A monovalent streptavidin with a single femtomolar biotin binding site. Nature Methods 2006, 3, 267-273. M. Howarth, D. J.-F. Chinnapen, K. Gerrow, P. C. Dorrestein, M. R. Grandy, N. L. Kelleher, A. El-Husseini, and A. Y. Ting.