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Hongwei Zhang

Hongwei Zhang, PhD

Director of BS Pharmaceutical Sciences Program

Associate Professor of Pharmaceutics

Department: School of Pharmacy
Office: W316

(P) 617.732.2969


School of Pharmacy


Pharmaceutical Sciences (BS)
Pharmaceutics (MS)
Pharmaceutics (PhD)


Postdoctoral Fellow, University of Massachusetts Medical School, Worcester, MA
PhD, Pharmaceutics, Sichuan University, Chengdu, China
BS, Pharmacy, Sichuan University, Chengdu, China

Research Interests

Drug Delivery
Gene Therapy

Peer-Reviewed Articles & Book Chapters

He, W., Turkeshi A., Li, X. & Zhang, H. (2020). Progress in systemic co-delivery of micro RNAs and chemotherapeutics for cancer treatment by using lipid-based nanoparticles. Therapeutic Delivery. 11(9): 591-603.

He, L., Yu, A., Deng, L., & Zhang, H. (2020). Eradicating the Roots: Advanced Therapeutic Approaches Targeting Breast Cancer Stem Cells. Current Pharmaceutical Design. 26(17): 1994-2008.

Alamri, A., Huang, Y. & Zhang, H. (2018). Liposomal nanoformulation of piperlongumine for improved aqueous solubility and enhanced anti-tumor activity in-vitro. International Journal of Pharmaceutics & Pharmacology, 2, 1-8.

Zhang, H. Thin-film hydration followed by extrusion method for liposome preparation. (2017). Methods in Molecular Biology, 1522:17-22. New York: Humana Press.

Zhang, H. Thin-film hydration followed by extrusion method for liposome preparation. (2016). Methods in molecular biology – Liposomes (second edition). New York: Humana Press.

Sadhu, S.S., Xie, J., Zhang, H., Perumal, O., and Guan, X. (2016). Glutathione disulfide liposomes - a research tool for the study of glutathione disulfide associated functions and dysfunctions. Biochemistry and Biophysics Reports, 7, 225-229.

Yang B, Li S, Wang H, Guo Y, Gessler DJ, Cao C, Su Q, Kramer J, Zhong L, Seher Ahmed S, Zhang H, He R, Desrosiers RC, Brown R, Xu Z, Gao G. Global CNS Transduction of Adult Mice by Intravenously Delivered rAAVrh.8 and rAAVrh.10 and Nonhuman Primates by rAAVrh.10. Mol Ther. 2014, 22(7): 1299-1309.

Ahmed SS, Li H, Cao C, Sikoglu EM, Denninger AR, Su Q, Eaton S, Liso Navarro AA, Xie J, Szucs S, Zhang H, Moore C, Kirschner DA, Seyfried TN, Flotte TR, Matalon R, Gao G. A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS gene therapy in Canavan mice. Mol Ther. 2013, 21(12): 2136 – 2147. PMID: 23817205.

Xie J, Ameres SL, Friedline R, Hung JH, Zhang Y, Xie Q, Zhong L, Su Q, He R, Li M, Li H, Mu X, Zhang H, Broderick JA, Kim JK, Weng Z, Flotte TR, Zamore PD and Gao G. Long-term, efficient inhibition of microRNA function in mice using rAAV vectors. Nat Methods. 2012 Mar 4;9(4):403-409. PMID: 22388288.

Zhang H, Yang B, Mu X, Ahmed S, Su Q, He R, Wang H, Mueller C, Sena-Esteves M, Brown BR, Xu Z and Gao G. Several rAAV vectors efficiently cross the blood-brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous system. Mol Ther. 2011, 19(8):1440-1448. PMID: 21610699.

Xie J, Xie Q, Zhang H, Ameres SL, Hung JH, Su Q, He R, Mu X, Seher Ahmed S, Park S, Kato H, Li C, Mueller C, Mello CC, Weng Z, Flotte TR, Zamore PD, Gao G. MicroRNA-regulated systemically delivered rAAV9: a step closer to CNS-restricted transgene expression. Mol Ther. 2011:19(3):526-535. PMID: 21179009.

Zhang H, Gerson T, Varney ML, Singh RK, Vinogradov SV. Multifunctional Peptide-PEG Intercalating Conjugates: Programmatic of Gene Delivery to the Blood-Brain Barrier. Pharm Res. 2010: 27(12):2528-2543. PMID: 20824308.

Zhang H and Vinogradov SV. Short biodegradable polyamines for gene delivery and transfection of brain capillary endothelial cells. J Control Release, 2010: 143(3):359-366. PMID: 20093156.

Zhang H, Xie J, Xie Q, Wilson JM and Gao G. Adenovirus-adeno-associated virus hybrid for large-scale recombinant adeno-associated virus production. Hum Gene Ther, 2009, 20(9): 922-929. PMID: 19618999.

Sun X*, Zhang HW*, Zhang ZR. Growth inhibition of the pulmonary metastatic tumors by systemic delivery of the p27 kip1 gene using lyophilized lipid-polycation-DNA complexes. J Gene Med, 2009, 11(6):535-544. PMID: 19326369. *:Equal contribution and shared first authorship

Zhang H, Mitin A and Vinogradov SV. Efficient transfection of blood-brain barrier endothelial cells by lipoplexes and polyplexes in the presence of nuclear targeting NLS-PEG-acridine conjugates. Bioconjug. Chem, 2009, 20(1): 120-128. PMID: 19067581.


2010  Postdoctoral Fellowship Award, American Heart Association
2010  Innovation in Biotechnology Award, American Association of Pharmaceutical Scientists
2009  Travel Fellowship Award, American Association of Pharmaceutical Scientists
2008  Travel Fellowship Award, American Association of Pharmaceutical Scientists
2008  Postdoctoral Travel Fellowship Award, University of Nebraska Medical Center
2005  QiuShi Graduate Scholarship, QiuShi Sciences & Technologies Foundation, Hong Kong
2004  First Place Ph.D. Candidate Scholarship, Sichuan University
1999  United Medical Education Undergraduate Scholarship, Sichuan University

Current Professional Memberships, Service & Leadership

Executive director - Sino-America Pharmaceutical Professional Association (SAPA) New England chapter
Member, Rho Chi National Pharmacy Honor Society
Member, American Association of Pharmaceutical Scientists
Member, Controlled Release Society
Advisory Editorial Board Member, Drug Delivery Letters
Advisory Editorial Board Member, Indian Journal of Novel Drug Delivery
Advisory Editorial Board Member, JSM Clinical Pharmaceutics
Ad hoc reviewer: ACS Nano, Human Gene Therapy, Journal of Controlled Release, Molecular Pharmaceutics, Pharmaceutical Research, International Journal of Pharmaceutics, Journal of Pharmaceutical Sciences, European Journal of Pharmaceutics and Biopharmaceutics, Journal of Biomedical Nanotechnology, Journal of Liposome Research, Theranostics, etc.