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The Conversion to Human Regular 500 Units/Ml Insulin Utilizing Continuous Glucose Monitoring (CGM)

This CE will briefly highlight the previous standard practice for administering U-500 and examine the current available delivery device options for safe and efficacious administration of human regular insulin 500 units/ml with a dedicated U-500 syringe and an insulin pen. The safe and effective use of U-500 requires careful monitoring to optimize glycemic control while minimizing the risk of hypoglyce­mia. The role, value and usage of continuous glucose monitoring (CGM) will be discussed and demonstrated throughout this session. This session will utilize a patient case example to highlight a candidate for U-500 insulin therapy, the transition to U-500, and appropriate therapy adjustments at various intervals.

Learning Objectives

Upon completion of this activity, the participant should be able to:

  • Identify candidates for human regular insulin 500 units/ml and discuss dosing strategies for its use
  • Explain the available delivery device options for safe and efficacious administration of human regular insulin 500units/ml with a dedicated U-500 syringe and an insulin pen
  • Recognize the benefits of continuous glucose monitoring to aid in the ability to dose human regular insulin 500 units/ml.


Jennifer Goldman, RPh, PharmD, CDE, BC-ADM, FCCP
Jennifer has been a pharmacist for 30 years and joined the faculty at MCPHS University in 1997. She received her BS in Pharmacy in 1990 and her Doctorate in Pharmacy in 1996, both from MCPHS University. She completed a residency with a focus in primary care at the Boston VA Medical Center in 1997 and is board certified in advanced diabetes management (BC-ADM) and is a certified diabetes educator (CDE). She is a fellow of the American College of Clinical Pharmacists (FCCP). She was clinical pharmacy faculty at Tufts University Family Residency Program from 1997 to 2011. Dr. Goldman is currently Professor of Pharmacy Practice and coordinates and teaches in various therapeutics courses in the pharmacy and physician assistant programs. She has maintained a practice in family and internal medicine with a focus in diabetes and cardiovascular disease since 1997. She practices at Well Life Medical in Peabody, MA. She is an academic preceptor for MCPHS University PharmD candidates and the academic fellowship preceptor for MCPHS University/Becton Dickinson fellows in diabetes care. She has served on various statewide and national organizational committees and boards. Her research interests are in the area of diabetes, cardiovascular disease and the scholarship of teaching with multiple publications and invited presentations in these areas.

Alexandra King, MCPHS Candidate for Doctor of Pharmacy '21


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Release Date: July 29, 2020
Expiration Date: July 21, 2022
Contact Hours: 1.0
ACPE UAN: 0026-0000-20-200-H01-P
ACPE Topic Designator: Drug Therapy

Registration Fee: Free to MCPHS Alumni and full-time employees; $12.00 for all other professionals.