Tewodros Eguale, MD, MS, PhD
Professor of Epidemiology and Biostatistics
he/him
School
School of Pharmacy
Department
School of Pharmacy
Office Location
MATR 4006G
Boston
Office Phone Office Phone: 617.732.2206
About
Dr. Eguale’s has seven years of clinical practice experience along with an M.Sc. degree (genetic epidemiology of tuberculosis), and a PhD (Novel use of EHRs to estimate the prevalence of off- label prescribing, determinants and its association with adverse drug events). His research includes comparative safety and effectiveness of drugs, pharmacosurveillance, measuring conservative prescribing practices, and medication adherence. His work has contributed significantly to priority areas identified by the WHO to incorporate active surveillance to drug monitoring. Dr. Eguale has done extensive research on off-label prescribing practices and physicians’ determinants of off-label prescribing. His research was the first to link off-label use to adverse drug events in adult population. Dr. Equale has done additional work that evaluated information technologies to improve medication safety using EHRs. His PhD and M.Sc. graduates are working in pharmaceutical industries (e.g. Merck), consulting firms, and universities.
Education
- M.D., M.Sc., PhD
Research Interests
- Clinician-Based Validation of MedAware System to Identify Patients at Risk of Opioid Use Disorder
- Evaluation of Personal Formularies of Primary Care Physicians Across Health Care Systems
- Comparative safety and effectiveness of antipsychotics for the treatment of dementia
- Comparative safety and effectiveness of amitriptyline (off-label) and other FDA approved drugs for fibromyalgia
- Cost-effectiveness analysis of drugs and surgical treatments.
- Measuring prevalence of off-label prescribing and identification of determinants of off-label prescribing.
- Development of an adverse drug event evaluation software
- Development, implementation and validation of new features in EHRs e.g. capturing reasons for drug discontinuations
- Evaluation of appropriateness of medication alert overrides and identification of determinants of medication alert overrides.
- Measurement of primary non-adherence, and elucidation of determinants including cost of medications, continuity of care and co-pays and deductibles
- Validation of data documentation of treatment indications and treatment outcomes using electronic health records.
Featured Affiliations
International Society for Pharmacoepidemiology (ISPE)
LinkInternational Society for Pharmacoeconomics and Outcome Research (ISPOR)
LinkAmerican Medical Informatics Association (AMIA)
LinkAmerican Association of Colleges of Pharmacy (AACP)
LinkEducation
- M.D., M.Sc., PhD
Research Interests
- Clinician-Based Validation of MedAware System to Identify Patients at Risk of Opioid Use Disorder
- Evaluation of Personal Formularies of Primary Care Physicians Across Health Care Systems
- Comparative safety and effectiveness of antipsychotics for the treatment of dementia
- Comparative safety and effectiveness of amitriptyline (off-label) and other FDA approved drugs for fibromyalgia
- Cost-effectiveness analysis of drugs and surgical treatments.
- Measuring prevalence of off-label prescribing and identification of determinants of off-label prescribing.
- Development of an adverse drug event evaluation software
- Development, implementation and validation of new features in EHRs e.g. capturing reasons for drug discontinuations
- Evaluation of appropriateness of medication alert overrides and identification of determinants of medication alert overrides.
- Measurement of primary non-adherence, and elucidation of determinants including cost of medications, continuity of care and co-pays and deductibles
- Validation of data documentation of treatment indications and treatment outcomes using electronic health records.
Publications
- Farag HM, Yunusa I, Goswami H, Sultan I, Doucette JA, Eguale T
Comparison of Amitriptyline and US Food Drug Administration-Approved Treatments fo Fibromyagia. JAMA Netw Open, 2022 - Galanter W, Eguale T, Gellad W, et al. Personal Formularies of Primary Care Physicians Across 4 Health Care Systems. JAMA Netw Open. 2021;4(7):e2117038. doi:10.1001/jamanetworkopen.2021.17038
- Yunusa I; Alsahali S, Rane A, Eguale T. ‘Comparative Value of Cholinesterase Inhibitors and Memantine in Persons with Moderate-to-Severe Alzheimer’s Disease in the United States: A Cost-Effectiveness Analysis’. Journal of Alzheimer's Disease Reports, vol. 5, no. 1, pp. 705-713, 2021.
- Extended duration venous thromboembolism prophylaxis with betrixaban for patients re- admitted with venous thromboembolism.
Fahmy M, Sylvester KW, Migliore M, Eguale T, Fanikos J, Connors JM, Goldhaber SZ
Journal of Thromb Thrombolysis (2021) Jul;52(1):22-29. - Detection of adverse drug events in e-prescribing and administrative health data: a validation study
Habib B, Tamblyn R, Girard N, Eguale T, Huang A, BMC Health Serv Res 21, 376 (2021) - Salazar, A, Karmiy, S., Forsythe, K., Amato, M, Wright, A, Lai, K, Lambert, B, Liebovitz, D, Eguale, T, Volk, L, & Schiff, G; How often do prescribers include indications in drug orders? Analysis of 4 million outpatient prescriptions (2019) Am J Health Syst Pharm. 2019 June 18;76(13):970‐979. doi:10.1093/ajhp/zxz082
- Yunusa, I; Alsumali, A; Garba, A; Regestein, Q; Eguale, T; Assessment of Reported Comparative Effectiveness and Safety of Atypical Antipsychotics in the Treatment of Behavioral and Psychological Symptoms of Dementia: A Network Meta-analysis JAMA Network Open 2019;2(3):e190828. doi:10.1001/jamanetworkopen.2019.0828
- Alsumali, A., Al-Hawag, A., Samnaliev, M., Eguale, T. Systematic assessment of decision
- analytic models for the cost effectiveness of bariatric surgery for morbid obesity. (In press) Surg Obes Relat Dis. 2018; 14 (7), 1041-1059
- Alsumali A, Al-Hawag A, Bairdain S, Eguale T. The impact of bariatric surgery on pulmonary function: a meta-analysis. Surg Obes Relat Dis. 2018 Feb;14(2):225-236.
- 1Alsumali A, Eguale T, Bairdain S, Samnaliev M. Cost-Effectiveness Analysis of Bariatric
Surgery for Morbid Obesity. Obes Surg. 2018; 28(8):2203-2214. - Garabedian, P; Wright, A; Newbury, I; Volk, L; Salazar, A; Amato, M; Nathan, A; Forsythe, K; Galanter, W; Kron, K; Myers, S; Abraham, J; McCord, S; Eguale, T; Bates, D; Schiff, G; Comparison of a Prototype for Indications-Based Prescribing With 2 Commercial Prescribing Systems JAMA Network Open; 2; 2019 2(3):e191514. doi:10.1001/jamanetworkopen.2019.1514
- Nanji KC, Seger DL, Slight SP, Amato MG, Beeler PE, Her QL, Dalleur O, Eguale T, Wong A,
Silvers ER, Swerdloff M, Hussain ST, Maniam N, Fiskio JM, Dykes PC, Bates DW. Medication- related clinical decision support alert overrides in inpatients. J Am Med Inform Assoc. 2018 May 1;25(5):476-481. - Kron K, Myers S, Volk L, Nathan A, Neri P, Salazar A, Amato MG, Wright A, Karmiy S, McCord S, Seoane-Vazquez E, Eguale T, Rodriguez-Monguio R, Bates DW, Schiff G. Incorporating medication indications into the prescribing process. Am J Health Syst Pharm. 2018 Apr 19. pii: ajhp170346.
- Wong J, Motulsky A, Eguale T, Buckeridge DL, Abrahamowicz M, Tamblyn R Off-label indications for antidepressants in primary care: a descriptive study of prescriptions from an indication-based e-prescribing system BMJ 2017; 356: j603
- Wong A, Amato MG, Seger DL, Slight SP, Beeler PE, Dykes PC, Fiskio JM, Silvers ER, EJ, Eguale T, Bates DW. Evaluation of medication-related clinical decision support alert overrides in the intensive care unit. J Crit Care. 2017 Jun;39:156-161.
- Eguale T, Verma A, Tamblyn R. Letters and comments: Association between off-label use and Adverse Drug Events. JAMA Intern Med. 2016;176(6):861-862. doi:10.1001/jamainternmed.2016.1406doi: 10.1001/jamainternmed.2016.
- Eguale T, Buckeridge DL, Verma A, Winslade NE, Benedetti A, Hanley JA, Tamblyn R. Association between off-label use and Adverse Drug Events. JAMA Intern Med 2016 Jan 1;176(1):55-63. doi: 10.1001/jamainternmed.2015.6058 [Online First, November 2 2015].
- Slight SP, Eguale T, Amato MG, Seger AC, Whitney DL, Bates DW, Schiff GD. The vulnerabilities of computerized physician order entry systems: a qualitative study. J Am Med Inform Assoc. 2015 Nov 13. pii: ocv135. doi: 10.1093/jamia/ocv135. [Epub ahead of print]
- Tamblyn R; Ernst P; Winslade N; Huang A; Grad R; Platt RW; Ahmed S; Moraga T; Eguale T; Evaluating the impact of an integrated computer-based decision support with person-centered analytics for the management of asthma in primary care: a randomized controlled trial J Am Med Inform Assoc 2015;22:773–783. doi:10.1093/jamia/ocu009
- Tian Z; Sun S; Eguale T; Rochefort CM; Automated Extraction of VTE Events from Narrative Radiology Reports in Electronic Health Records: A Validation Study. Medical care 2015 DOI: 10.1097/MLR.
- Alqahtani S; Seoane‐Vazquez E; Rodriguez‐Monguio R; Eguale T; Priority review drugs approved by the FDA and the EMA: time for international regulatory harmonization of pharmaceuticals? Pharmacoepidemiology and drug safety 2015, 24(7):709-715
- Schiff GD, Amato MG, Eguale T, Boehne JJ, Wright A, Koppel R, et al. Computerised physician order entry-related medication errors: analysis of reported errors and vulnerability testing of current systems. BMJ Quality & Safety. 2015 [Online First: 16/01/2015] doi:10.1136/bmjqs-2014-003555
- Rochefort CM, Verma AD, Eguale T, TC Lee, DL Buckeridge. A novel method of adverse event detection can accurately identify venous thromboembolisms (VTEs) from narrative electronic health record data J Am Med Inform Assoc [Online First: 21/10/2014] doi:10.1136/amiajnl-2014-002768
- T Eguale, M Amato, SP Slight, AC Seger, DL Whitney, DW Bates, GD Schiff Where do current computerized physician order entries (CPOEs) stand in averting/facilitating medication errors in the United States and Canada? Journal of Gen Inter Medicine 29, s256-s257
- SP Slight, T Eguale, M Amato, AC Seger, DL Whitney, DW Bates, GD Schiff. A qualitative study exploring the vulnerabilities of computerized physician order entry systems. Journal of General Internal Medicine, 2014, Vol.29, pp.s12-s13
- Tamblyn R, Eguale T, Huang A, Winslade N, Doran P. The Incidence and Determinants of Primary Non-Adherence with Prescribed Medication in Primary Care: A Cohort Study. Annals of Internal Medicine, 2014 Apr 1;160(7): 441-450
- Krotneva SP, Ramjaun A, Reidel KE, Eguale T, Trabulsi N, Mayo N, Tamblyn R, Meguerditchian AN. Hormonal Therapy Use in Senior Breast Cancer Patients Treated With or Without Radiotherapy. Current Oncology, Vol. 21, pp. e105-115.
- Eguale T, Buckeridge DL, Winslade NE, Benedetti A, Hanley JA, Tamblyn R. Drug, patient, and physician characteristics associated with off-label prescribing in primary care. Arch Intern Med 2012 May 28;172(10):781-8. [CIHR Institute of Health Services and Policy Research CIHR- IHSPR, Article of the Year Award, $10,000]
- Eguale T, Tamblyn R, Winslade N, Buckeridge D. Detection of adverse drug events and other
treatment outcomes using an electronic prescribing system. Drug Saf 2008;31(11):1005-16. - Eguale T, Winslade N, Hanley JA, Buckeridge DL, Tamblyn R. Enhancing pharmacosurveillance with systematic collection of treatment indication in electronic prescribing: a validation study in Canada. Drug Saf 2010 Jul 1;33(7):559-67.
- Eguale T, Bartlett G, Tamblyn R. Rare visible disorders/ diseases as individually iden health information. AMIA Annu Symp Proc 2005;947.
- Eguale T, Abate G, Balcha F. Relapsing fever in Hossana, Ethiopia: a clinical and epidemiological study. Ethiop J Health Sci 2002;12(2):103-8.
- TY Wang, T Eguale, R Tamblyn Guidelines adherence in the treatment of patients with newly diagnosed type 2 diabetes: a historical cohort comparing the use of metformin in Quebec pre and post-Canadian Diabetes Association guidelines. BMC health services research (2013) 13 (1), 442
- Tamblyn R, Eguale T, Buckeridge DL, Huang A, Hanley J, Reidel K, Hanley J, Reidel K, Shi S, Winslade N. The effectiveness of a new generation of computerized drug alerts in reducing the risk of injury from drug side effects: a cluster randomized trial. J Am Med Inform Assoc 2012 Jan 12.
- Forster A, Oake N, Ali M, Augur , Eguale T. Using information technology to improve the monitoring of outpatient prescribing. JAMA internal medicine (2013) 173 (5), 382-384
- Tamblyn R, Huang AR, Meguerditchian AN, Winslade NE, Rochefort C, Forster A, Eguale T,
Buckeridge D, Jacques A, Naicker K, Reidel KE. Using novel Canadian resources to improve medication reconciliation at discharge: study protocol for a randomized controlled trial. Trials 2012;13:150. - Tamblyn R, Abrahamowicz M, Dauphinee D, Wenghofer E, Jacques A, Klass D, Smee S, Eguale T, Winslade N, Girard N, Bartman I, Buckeridge DL, Hanley JA. Influence of physicians' management and communication ability on patients' persistence with antihypertensive medication. Arch Intern Med 2010 Jun 28;170(12):1064-72.
- Malik S, Greenwood CMT, Eguale T, Kifle A, Beyene J, Habte A, Tadesse, Schurr E. Variants of the SFTPA1 and SFTPA2 genes and susceptibility to tuberculosis in Ethiopia. Human genetics 118 (6), 752-759
- Meguerditchian AN, Dauphinee D, Girard N, Eguale T, Riedel K, Jacques A, Meterissian S, Buckeridge DL, Abrahamowicz M, Tamblyn R. Do physician communication skills influence screening mammography utilization? BMC Health Serv Res 2012;12:219.
- Huang AR, Mallet L, Rochefort CM, Eguale T, Buckeridge DL, Tamblyn R. Medication-related falls in the elderly: causative factors and preventive strategies. Drugs Aging 2012 May 1;29(5):359-76.
- Kennie-Kaulbach N, Farrell B, Ward N, Johnston S, Gubbels A, Eguale T, Dolovich L, Jorgenson D, Waite N, Winslade N. Pharmacist provision of primary health care: a modified Delphi validation of pharmacists' competencies. BMC Fam Pract 2012;13:27.
- Solomon G, Eguale T, Abebe G, Abate G. Disease-Related Knowledge and Practices of Tuberculosis Patients. Ethiop J Health Sci 13 (1), 71-76
- Demissie A, Ravn P, Olobo J, Doherty TM, Eguale T, Geletu M, Hailu W, Andersen P, Britton S. T-cell recognition of Mycobacterium tuberculosis culture filtrate fractions in tuberculosis patients and their household contacts. Infect Immun 1999 Nov;67(11):5967-71.
- Doherty TM, Demissie A, Olobo J, Wolday D, Britton S, Eguale T, Ravn P, Andersen P. Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients. J Clin Microbiol 2002 Feb;40(2):704-6.
- Olobo JO, Geletu M, Demissie A, Eguale T, Hiwot K, Aderaye G, Britton S. Circulating TNF- alpha, TGF-beta, and IL-10 in tuberculosis patients and healthy contacts. Scand J Immunol 2001 Jan;53(1):85-91.
- Ravn P, Demissie A, Eguale T, Wondwosson H, Lein D, Amoudy HA, Mustafa AS, Jensen AK, Holm A, Rosenkrands I, Oftung F, Olobo J, von Reyn F, Andersen P. Human T cell responses to the ESAT-6 antigen from Mycobacterium tuberculosis. J Infect Dis 1999 Mar;179(3):637-45.
Awards and Honors
- 2020 Annual Scholarship Awards, Scholarship of Discovery (basic or applied research; research), MCPHS University ($1,250)
- 2018 Group Award, Towards better assessment of PharmD-Boston educational outcome through the mapping of exam questions; Winner of $250, Assessment Competition, Annual MCPHS University Show Case
- 2018 Group Award, 2017 Partners in Excellence Award in the area of Indication Based Prescribing, Boston, MA
- 2016 Best poster finalists, 2 MSc students; International Society for Pharmacoeconomics and Outcome Research
- 2015 Group Award, 2014 Partners in Excellence Award in the area of Leadership and Innovation, Boston, MA
- 2013 CIHR Institute of Health Services and Policy Research (CIHR-IHSPR) on off-label use published in JAMA Internal Medicine, 2012/13 Article of the Year Award, $10,000
- 2009 McGill University Health Center Research Institute, Health Outcomes Axis, 2nd best oral Presentation, $250
- 2011 McGill University Health Center Research Institute, Health Outcomes Axis, 2nd best oral Presentation, $200