Gerard D'Souza, Ph.D
Professor of Pharmaceutics
School
School of Pharmacy
Department
Pharmaceutical Sciences
Office Location
White 311
Boston
Office Phone Office Phone: 617.735.1091
Mobile Phone Mobile Phone: 617.735.1091
About
Dr. D’Souza earned his PhD in 2005 and completed three years of postdoctoral training before joining MCPHS as an Assistant Professor in 2008. Since that time, he has taught extensively across undergraduate and graduate programs and has served on numerous School and University committees.
He maintains an active research program, mentoring more than 30 student researchers and securing National Institutes of Health (NIH) funding in support of his work. In addition to his faculty responsibilities, Dr. D’Souza has served on the School of Pharmacy–Boston executive team in roles related to assessment and accreditation since 2013 and currently holds the position of Assistant Dean of Assessment and Accreditation.
Education
- PhD, Northeastern University
- MS, Northeastern University
- BPharm, Goa College of Pharmacy, Panaji, Goa, India
Research Interests
- Pharmaceutical Nanocarriers
- Subcellular Targeting
- Mitochondrial DNA Diseases
Programs
- Clinical Investigation and Development (MS)
- Clinical Research (MS)
- Medicinal Chemistry (MS)
- Medicinal Chemistry (PhD)
- Pharmaceutical Business (BS)
- Pharmaceutical Sciences (BS)
- Pharmaceutics (MS)
- Pharmaceutics (PhD)
- Pharmacology & Toxicology (BS)
- Pharmacology (MS)
- Pharmacology (PhD)
- Pharmacy (PharmD)—Direct Entry
- Pharmacy (PharmD)—Non-Traditional Pathway
- Regulatory Affairs & Health Policy (MS)
- Regulatory Sciences (MS)
- Clinical Research Graduate Certificate
- Health Policy Graduate Certificate
- Regulatory Affairs Graduate Certificate
Featured Affiliations
Associate Editor, Journal of Liposome Research
Editorial Board Member, Drug Delivery
Education
- PhD, Northeastern University
- MS, Northeastern University
- BPharm, Goa College of Pharmacy, Panaji, Goa, India
Research Interests
- Pharmaceutical Nanocarriers
- Subcellular Targeting
- Mitochondrial DNA Diseases
Programs
- Clinical Investigation and Development (MS)
- Clinical Research (MS)
- Medicinal Chemistry (MS)
- Medicinal Chemistry (PhD)
- Pharmaceutical Business (BS)
- Pharmaceutical Sciences (BS)
- Pharmaceutics (MS)
- Pharmaceutics (PhD)
- Pharmacology & Toxicology (BS)
- Pharmacology (MS)
- Pharmacology (PhD)
- Pharmacy (PharmD)—Direct Entry
- Pharmacy (PharmD)—Non-Traditional Pathway
- Regulatory Affairs & Health Policy (MS)
- Regulatory Sciences (MS)
- Clinical Research Graduate Certificate
- Health Policy Graduate Certificate
- Regulatory Affairs Graduate Certificate
Publications
- Shah S, Kim Y, Pulak R, D'Souza GGM. (2025) Triple co-culture spheroid models of lung and ovarian carcinoma cell lines for the in vitro testing of antitumor liposomes. J Liposome Res. 2025 Jun 5:1-13.
- Shah S, D'Souza GGM. (2025) Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis. Cells. May 17;14(10):732.
- MiMb:Liposomes Third edition (2022), GGM D'Souza and H Zhang, Editors, Springer Publishers.
- Shah S, Ouellette M, D'Souza GGM. (2022) In Vitro assessment of stearyl triphenylphosphonium toxicity in drug resistant tumor cells. 4Open. 5, 6.
- Vyas V, Solomon M, D'Souza GGM, Huey BD. (2019) Nanomechanical Analysis of Extracellular Matrix and Cells in Multicellular Spheroids. Cel. Mol. Bioeng.
- Ganpule A, Gui Z, Almuteri MA, D'Souza GGM. (2019) In Vitro Testing of Anticancer Nanotherapeutics Using Tumor Spheroids. Methods Mol Biol. 2000:387-393.
- Benien P, Solomon MA, Nguyen P, Sheehan EM, Mehanna AS, D'Souza GG. (2016) Hydrophobized triphenyl phosphonium derivatives for the preparation of mitochondriotropic liposomes: choice of hydrophobic anchor influences cytotoxicity but not mitochondriotropic effect. J Liposome Res. 26(1):21-7.
- Elsaid KA, Ubhe A, Shaman Z, D'Souza G. (2016) Intra-articular interleukin-1 receptor antagonist (IL1-ra) microspheres for posttraumatic osteoarthritis: in vitro biological activity and in vivo disease modifying effect. J Exp Orthop. Dec;3(1):18.
- Solomon MA, Lemera J, D'Souza GG. (2016) Development of an in vitro tumor spheroid culture model amenable to high-throughput testing of potential anticancer nanotherapeutics. J Liposome Res. Sep;26(3):246-60.
- SV Boddapati, GGM D'Souza, S Erdogan, VP Torchilin, V Weissig (2008) Organelle-targeted nanocarriers: Specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo. Nanoletters Jul 9.
- E Katrangi, GGM D'Souza, BW Bigger, M Kulaweizk, K Singh, V Weissig. (2007) Xenogenic transfer of isolated murine mitochondria into human Rho0 cells can improve respiratory function. Rejuvenation Research Dec;10(4):561-70.
- Torchilin VP, Levchenko TS, Rammohan R, Volodina N, Papahadjopoulos-Sternberg B, D'Souza GG. (2003). Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome-DNA Complexes. Proc Natl Acad Sci U S A. Feb 18;100(4):1972-7.
Awards and Honors
- 2019 Phi Lambda Sigma, Pharmacy Leadership Society, Faculty Inductee
- 2014 Phi Kappa Phi, Honor Society, Charter member
- 2012 World Congress on Targeting Mitochondria, Scientific Contribution Award 2012 Sigma Xi, Scientific Research Society, Member
- 2011 Rho Chi, Pharmaceutical Honor Society, Faculty Inductee
- 2003 John L Neumeyer Research Fellowship