School
School of Professional Studies
Department
School of Professional Studies
About
Education
- PhD in Immunology, University of Pennsylvania
- BS in Chemical Engineering, Rice University
Research Interests
- Specific targeting of therapeutics
- Radiotherapy
- Cytokine engineering
Featured Affiliations
American Association for Cancer Research
WebsiteEducation
- PhD in Immunology, University of Pennsylvania
- BS in Chemical Engineering, Rice University
Research Interests
- Specific targeting of therapeutics
- Radiotherapy
- Cytokine engineering
Publications
SELECTED PATENT APPLICATIONS, PRESENTATIONS, AND PUBLICATIONS- R. Rozenfeld, U. Eskiocak, H. Qiu, P. Johnson, K.A. Jenkins, M. Pederzoli-Ribeli, D.S. Tomar, and R. O'Donnell (2021). Masked IL-2 cytokines and their cleavage products. WO2021202675A1.
- R. Rozenfeld, U. Eskiocak, H. Qiu, P. Johnson, K.A. Jenkins, M. Pederzoli-Ribeli, D.S. Tomar, and R. O'Donnell (2021). Masked IL-12 cytokines and their cleavage products. WO2021202678A1.
- R. Rozenfeld, U. Eskiocak, H. Qiu, P. Johnson, K.A. Jenkins, M. Pederzoli-Ribeli, D.S. Tomar, and R. O'Donnell (2021). Masked IL-15 cytokines and their cleavage products. WO2021202673A2.
- E. Patel, N.V. Malkova, D. Crowe, M. Pederzoli-Ribeil, D. Fantini, M. Fanny, H.R. Madala, K.A. Jenkins, O. Yerov, J. Greene, W. Guzman, C. O'Toole, J. Taylor, R.K. O'Donnell, P. Johnson, B.B. Lanter, B. Ames, J. Chen, S. Vu, H. Wu, S. Cantin, M. McLaughlin, Y. S. Hsiao, D.S. Tomar, R. Rozenfeld, L. Thiruneelakantapillai, R.C. O'Hagan, B. Nicholson, J. O'Neil, and C.U. Bialucha. XTX301, a tumor-activated Interleukin-12, has the potential to widen the therapeutic index of IL-12 treatment for solid tumors as evidenced by preclinical studies. Molecular Cancer Therapeutics, 23:421-435, 2024.
- W. Guzman, H.R. Madala, H. Duprey, M. Fanny, J. Greene, S. Hsiao, P. Johnson, C. O'Toole, J. Taylor, N. Malkova, R. O'Donnell, M. Pederzoli-Ribeil, B. Nicholson, J. O'Neil, and C.U. Bialucha. XTX202, a tumor-selective protein-engineered IL-2, exhibited enhanced anti-tumor activity in combination with checkpoint inhibition in mice. Poster presented at the 2022 Society for Immunotherapy of Cancer's (SITC) 37th Annual Meeting.
- J. O'Neil, W. Guzman, O. Yerov, P. Johnson, M. Fanny, J. Greene, M. McLaughlin, K. Jenkins, R. O'Donnell*, N. Malkova, E. Patel, H. Qiu, and B. Nicholson. Engineering geographically precise cytokines to achieve improved therapeutic benefit in oncology and beyond. Poster presented at the 2021 International Cytokine & Interferon Society annual meeting.
- O'Donnell, R. Organic Chemistry Nomenclature Workbook. May 13, 2019. https://cnx.org/contents/CnMUDUyD@3.12:ryMX59oT@4/Unbranched-Alkanes
- R.K. O'Donnell, B. Falcon, J. Hanson, W.E. Goldstein, C. Perruzzi, W.C. Aird, S. Rafii, L.E. Benjamin. VEGF-A/VEGFR inhibition restores hematopoietic homeostasis in the bone marrow and attenuates tumor growth. Cancer Research, 76:517-24, 2016.
- G. Zhang, L. Yang, G.S. Kim, K. Ryan, S. Lu, R.K. O'Donnell, K. Spokes, N. Shapiro, W.C. Aird, M.J. Kluk, K. Yano, T. Sanchez. Critical role of sphingosine-1-phosphate receptor 2 (SIPR2) in acute vascular inflammation. Blood, 122:443-55, 2013.
- R.K. O'Donnell, W.E. Goldstein, C. Perruzzi, L.E. Benjamin, W. Aird. Overexpression of MyrAkt1 in endothelial cells leads to erythropoietin- and BMP4-independent splenic erythropoiesis in mice. PloS One, 8:e55095, 2013.
- H. Kobayashi, J.M. Butler, R. O'Donnell, M. Kobayashi, B. Ding, B. Bonner, V.K. Chiu, D.J. Nolan, K. Shido, L. Benjamin, S. Rafii. Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells. Nature Cell Biology, 12:1046-56, 2010.
- R.K. O'Donnell, M. Feldman, R. Mick, R.J. Muschel. Immunohistochemical method identifies lymphovascular invasion in a majority of oral squamous cell carcinomas and discriminates between blood and lymphatic vessel invasion. Journal of Histochemistry and Cytochemistry, 56:803-10, 2008.
- R.K. O'Donnell, R. Mick, M. Feldman, S. Hino, Y. Wang, M.S. Brose, R.J. Muschel. Distribution of dendritic cell subtypes in primary oral squamous cell carcinoma is inconsistent with a functional response. Cancer Letters, 255:145-152, 2007.
- R.K. O'Donnell, M. Kupferman, S.J. Wei, S. Singhal, R. Weber, B. O'Malley Jr., Y. Cheng, M. Putt, M. Feldman, B. Ziober, and R.J. Muschel. Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity. Oncogene, 24:1244-51, 2005.
- Bhadra R, Wayment DG, Williams RK, Barman SN, Stone MB, Hughes JB, Shanks JV. Studies on plant-mediated fate of the explosives RDX and HMX. Chemosphere, 44:1259-64, 2001.
- Best iPoster in section, International Cytokine & Interferon Society annual meeting, 2021.
- Excellence in Poster Presentation Award, 2012. Awarded by faculty of the Center for Vascular Biology Research, BIDMC.
- Excellence in Research Presentation Award, 2010.
- Peer-awarded by fellows and students of the Center for Vascular Biology Research, BIDMC.