Bicara Therapeutics Fellowships
About Bicara Therapeutics
Bicara is a clinical-stage biopharmaceutical company committed to bringing transformative bifunctional therapies to patients with solid tumors. Bicara has built a platform designed to facilitate the development of bifunctional therapies that precisely target the tumor and deliver a tumor-modulating payload to the tumor site. This approach was deployed in the development of Bicara’s lead program ficerafusp alfa, formerly BCA101, a bifunctional epidermal growth factor receptor (EGFR) directed monoclonal antibody bound to a human transforming growth factor beta (TGF-β) ligand trap. By combining these two clinically validated targets, ficerafusp alfa has the potential to exert potent anti-tumor activity by simultaneously blocking both cancer cell-intrinsic EGFR survival and proliferation, as well as the immunosuppressive TGF-β signaling within the tumor microenvironment (TME). Ficerafusp alfa directs the TGF-β inhibitor into the immediate TME through the binding of EGFR on tumor cells, which Bicara believes will lead to deep and durable responses and an increase in overall survival, while reducing the potential adverse effects previously associated with systemic TGF-β inhibition. Ficerafusp alfa is being developed in head and neck squamous cell carcinoma, where there remains a significant unmet need, as well as other solid tumor types.
For more information, please visit www.bicara.com or follow us on LinkedIn and X.
Bicara/MCPHS Fellowship Program
The Bicara/MCPHS PharmD Fellowship Program was established to bridge academic training with meaningful biopharmaceutical industry experience. Through two distinct two-year fellowship programs, fellows gain broad exposure to the pharmaceutical industry landscape while developing practical, hands-on experience across key functional areas. Both fellowship positions are based out of Bicara Therapeutics' headquarters in Boston, Massachusetts:
- Global Drug Safety (1 position)
- Global Regulatory Affairs (1 position)
Our brochure will be coming soon.
If you have any questions or would like more information, please contact us at pharmdfellowships@bicara.com.